Human CYP1A1 Structure and Use in Understanding Metabolism
نویسندگان
چکیده
Background: Human cytochrome P450 1A1 (CYP1A1) activates procarcinogens but the basis of their binding is unknown. Results: A 2.6 Å structure with the inhibitor αnaphthoflavone and docking simulations suggest key active site features. Conclusion: CYP1A1 has a planar active site that restricts ligand orientations. Significance: This provides a useful framework for understanding CYP1A1 interactions with a variety of substrates and inhibitors.
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